![]() ![]() Heterogeneity of coenzyme Q10 deficiency: patient study and literature review. The optimal dosage of CoQ10 for improving fertility is not yet established, but studies have used doses ranging from 100600 mg per day, taken in divided doses. Banach M, Serban C, Ursoniu S, et al: Statin therapy and plasma coenzyme Q10 concentrations-A systematic review and meta-analysis of placebo-controlled trials. Hargreaves I, Heaton RA, Mantle D: Disorders of human coenzyme Q10 metabolism: An overview. Littarru GP, Tiano L: Clinical aspects of coenzyme Q10: An update. Desbats MA, Lunardi G, Doimo M, Trevisson E, Salviati L: Genetic bases and clinical manifestations of coenzyme Q10 (CoQ 10) deficiency. Depending on the clinical presentation, a common oral dosage for CoQ10 begins at 30 mg daily for general wellness and prevention and can be as high as 400 mg daily for heart disease and angina. In: Adam MP, Ardinger HH, Pagon RA, et al. Salviati L, Trevisson E, Doimo M, Navas P: Primary coenzyme Q10 deficiency. Additionally, the redox status of CoQ10 may be a useful early marker for the detection of oxidative LDL modification.ġ. ![]() CoQ10 may also play a role in hydroxymethylglutaryl-CoA reductase inhibitor (statin) therapy changes in CoQ10 may be relevant to statin-induced myalgia. Treatment with CoQ10 in patients with mitochondrial cytopathies can improve mitochondrial respiration in both brain and skeletal muscle.ĬoQ10 has been implicated in other disease processes, including Parkinson disease, diabetes, and Alzheimer disease, as well as in aging and oxidative stress. Isolated myopathy (exercise intolerance, fatigue, elevated serum CK) Nephropathy, steroid resistant nephrotic syndrome leading to end stage kidney disease Severe multisystemic infant form (nystagmus, optic atrophy, sensorineural hearing loss, dystonia, rapidly progressing nephropathy) Cerebellar ataxia and atrophy (neuropathy, hypogonadism) It is eaten in small amounts in meats and seafood. Encephalomyopathy (elevated serum creatine kinase, recurrent myoglobinuria, lactic acidosis) Coenzyme Q10 is a vitamin-like substance found throughout the body, but especially in the heart, liver, kidney, and pancreas. CoQ10 is present in the body in both the reduced and oxidized forms, with the antioxidant activity of CoQ10 dependent on both its concentration and its reduction-oxidation (redox) status.ĬoQ10 deficiencies, which are clinically and genetically diverse, can occur due to defects in genes involved in the biosynthesis of ubiquinone (primary CoQ10 deficiency) or due to other causes such as mitochondrial disorders (secondary or CoQ10 deficiency).įive major clinical phenotypes of CoQ10 deficiency have been described: Approximately 60% of CoQ10 is associated with low-density lipoprotein (LDL), 25% with high-density lipoprotein, and 15% with other lipoproteins. ![]() It is found in all cell membranes and is carried by lipoproteins in the circulation. Coenzyme Q10 (CoQ10) is an essential cofactor in the mitochondrial respiratory chain responsible for oxidative phosphorylation where it functions as an electron carrier and acts as an antioxidant. ![]()
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